A 600 is overkill for a 5.7 going 5000 rpm, as it is using less than 430 CFM.
When I have the 2bbl 500cfm Holley on my 5.7, the engine has about 4.5-5 inches of Manifold Vacuum at WOT(4800 rpm), which indicated that the 2bbl(which when tested like a 4bbl, flows about 375 CFM) was a bit undersized. When I put the Holley 650 spreadbore on, I gained about 550 rpm, and had to reprop, to bring the rpms down to 5000. In this configuration, the Manifold Vacuum was at 1.5", the Secondaries were far from fully open. Even though the engine was making more HP at the top end, I lost Holeshot because of the higher pitched prop. The tiny Primaries on the Spreadbore, may have helped in reducing the loss of Hole Shot.