Back when I taught people to land an aircraft, the last thing a new guy would learn is to account for the winds. He'd do fine one day and couldn't get close to a safe landing the next because the wind had changed. As a result, I always look at the flagpole at my marina before docking. We have no water currents so the wind is the only thing that changes from day to day. The flag tells me the direction, variability and strength of the wind. So when I line up and aim well right of the slip from a hundred feet out, my passengers used to get nervous. Having seen it all end well many times, they don't notice any more.
I would think wind on a houseboat would be the biggest factor in maneuvering. After that, its the mass of the boat that will keep it moving well after the engine is in idle. Finally, I'd be concerned about the fact that I can't reach out with a boathook just anywhere given the walls. If I were on a houseboat with other people, I'd make sure several of them were briefed well in advance and prepared to help when docking.