Re: Ohio River-E. Liverpool
You need to go from E. Liverpool to Pittsburgh to get any kind of "scenery". Actually the entire Ohio River is not especially scenic. It's a very deep river valley, so you don't see out of it. It's also one of the busiest commercially navigable rivers in the world.
I guess it's less ugly between Cincy and Louisville, KY, but it's not particularly beautiful, in my opinion. It's pretty desolate between Cincy and Hunington and Parkersburg. At least that's the way I remember it, from the time I was on it it 1999.
The area around Parkersburg, West Virginia isn't too bad. Seeing Aaron Burr's mansion on Blennerhesset Island is cool. Also a trip up the Muskingham River is supposed to be special.