If there is some fuel already in the tank, gas and oil mixing is easier than if the tank is dry. For example, if you were to pour a gal of oil into an empty fuel tank, and then pump 50 gal of gas into the tank, the fuel will not be mixed completely for a while. Adding the oil, and then adding the gasoline to a partially filled tank works just fine. It is best to make the mix as close to 50::1 as possible, so if there is any doubt about how much gasoline you need, mix it in increments. To mix in increments: If you think you need 21 gal of gas to fill up, you could toss in 56 oz of oil and then fill it. If your fuel estimate is off by several gallons, which is possible when estimating that amount of fuel, the mix ratio will be off. Alternatively, add 1 qt of oil and then 12 Gal gasoline. If the tank looks at least 6 gal low, add 1 pint of oil and 6 gal of gasoline. If she still looks like she will take 3 gal more, add 8 oz oil and then 3 gal gasoline. This method will help the oil to mix, and help elimate the error in estimating. If you miss it by a gal, it won't be much of an impact.