Scott, my 95 had an electric fuel pump, so that must be right around the switchover.
Theres also a bunch of odds and ends you will need to swap over... I think everything converts but I could be mistaken... I believe the s10 motor will have a serpentine belt, so you will need to swap over the pulley, and if its an automatic transmission, you will need to swap over the flywheel which SHOULD bolt up.
I recall running into a few other issues on mine, but it was all reasonably straight forward...
I will tell you though, it is MUCH easier if you get the same vintage motor. That being said, vortec heads are a good investment. So there are pros and cons to weigh out.