Depends on the "350"? If it's a 1983 OMC 5.7L marine bobtail, like this one (note no power steering)
it's a pretty simple swap assuming there is room in front of your current V6, and easier if your V6 setup has power steering if you would want ps on the V8.
You would need different gearing in the upper gearcase of the sterndrive (lower unit is the same).
If the "350" you mean is a long block or a car engine or something, then you need so many little obsolete parts it's not worth it.
And if the 350 has a 1 pc rear main seal, it won't work under any circumstance.
Put a Qjet on the 3.8 and it makes an honest 185HP.