Its a big job, no doubt, but possible. It all depends on how far you want to go. I am facing the same job on my 69' Revel Craft. Re-coring the hull is basically going to mean completely stripping the inside of the hull to the outer skin. Cleaning and grinding the interior of it, laying in new core and reglassing it. Then build up from there with new stringers, bulkheads and wings.
One huge challenge is supporting the shear weight of the structure with all of the supports removed. This is compounded in larger boats. How big is yours? I assume you are working in a larger boat. The example below is on a small 16 foot runabout. My Revel Craft is 24' and much larger.
Picture this on a large scale.
I build this hull form to support the hull so that it would keep its shape.
I flipped the structure back over on its top and it rested in the form until all the glass work was done.
Imagine that on a big boat! One option would be to do the work in sections supporting the hull in sections as you go. Bur it is definitely going to be a challenge. I have researched cored hulls and looked at some projects were sections of rotted core were replaced, but never a complete hull. Its pretty intimating, but it can be done. Another option would be to build temporary supports on the inside of the hull. But that is going to mean working around them as you remove the rotten stuff and replace it.
I do not look forward to re-coring that big old boat. But knowing me, I;ll do it anyway. If you decide to tackle yours we can share the pain.