Motorhomes, towing, tall tires, and high numeric gear ratios (4.56 & up) can all generate a lot of heat and cause the gear oil to break down. The greatest damage to a new gear set results from running for ten minutes or more during the first 500 miles when the oil is very hot. Any heavy use or overloading while the oil is extremely hot will cause it to break down and allow irreversible damage to the ring & pinion.
In order to make them run cooler and quieter, new gears are lapped at the factory. However, they are not lapped under the same pressures that driving creates. The loads generated while driving force any microscopic high spots on the gear teeth back into the surface of the metal. This is called "work hardening". Work hardening is similar to forging in the way that it compresses the metal molecules into a very compact and hard formation. This can only be accomplished if the metal surfaces are lubricated and the gear temperature stays cool enough that the molecular structure does not change. If the temperature of the metal gets hot enough to change the molecular structure, it will soften the surface instead of hardening it. This may seen like a balancing act, but it all happens easily and passively as long as the oil keeps the gear cool while it is breaking in. Some of the synthetic oils on the market today can help a gear set live longer. I've had great success with Red Line ®, Torco ®, and Richmond Gear ® synthetic gear oils. These oils will continue to lubricate at temperatures where many crude oils break down.