My project over the last 5 years or so started as a 1983 Aloha with 23" tubes with a 40 HP. I've made too many changes to count but at this point I've added a third toon that has in-floor storage, a built in fuel tank, a 200 HP transom and lifting strakes. It's a "U" tube that's 25" deep so it hangs down slightly from the others. I had a old 140 Evinrude on the twin toon but I changed it to a '94 Johnson 150 Fast Strike with a 4 blade PT prop. The last time I had it out last summer I clocked it at 40 MPH GPS. The boat has aluminum under-skinning.
I had lifting strakes added to the old outer toons and had some trouble with leaks but should be fixed now but haven't had it on the water yet since the repairs were made. The bottom line on my trouble was there were some repair welds on the original toons at some of the tube joints that had been tight for a few years but when the strakes were installed over them they started leaking again. I would make sure to not put the strakes over repaired areas. Also, the welder was an experienced aluminum welder but not so much on pontoons. He also user a spool gun that he was not experienced in using. The other suggestion I would make is to turn the boat over for the welder so they don't have to do it overhead. If you put all that together you can have a nightmare on your hands with leaks like I did.
I would for sure stay above 20 feet because the builder rules shift from Coast Guard to ABYC standards plus you have more stability. I never liked the way the twin toon turned but I never had strakes on the twin toon. I did have a Pontoon Water Glide under it for a few years and I can't say enough good things about it. It was actually faster than the third toon. The down side to the water glide, and what I was looking for, was more flotation, storage and I thought the third toon would run faster. I got everything I was looking for but slightly slower with the third toon.
Bryan is right in that you'll have to get to 200 HP+ to see 50 MPH. From 150 HP and up is where the third too will be needed in my opinion. As you look around you'll see a line around 150 HP that leans towards tri-toons. In my experience, I would agree with it. I love the way my boat runs and glides on the water and wouldn't go back to a twin toon. We use it for cruising, camping on the lake, hauling stuff to islands, tubing, skiing and some fishing with a trolling motor to clamp on when I want it.
Mark