check fuel supply for proper operation and clean the carbs. Mix screw is not for WOT.
It is for the idle mix adjustment.
If you run one or more cylinders lean it will eat pistons, so clean carbs real good and make sure you do the sync and like when put back on. A Yamaha service/repair manual is really a necessity for working on your motor.
Here is something from the frequently asked questions that is always good to do just to make sure your fuel supply is good. http://forums.iboats.com/showthread.php?t=283363
The vacuum/ pressure test will tell you if there is a restriction and if the pump is working properly.