While a flipped vane could damage the impeller, would not make it more difficult to rotate the driveshaft. If you want to reduce the friction of the impeller when rotating the driveshaft by hand, when you reassemble the water pump, lube the impeller with a silicone or
glycerin(K-Y Jelly) based, especially the top and bottom
Just make sure you install the impeller with the vanes curled the proper way. BTW the pic shows the view of the impeller looking down from above, backwards from what it will look like when you are looking into the pump bottom.
Flyingscott in the next post is dead on. Sometimes the prop will spin in neutral just because of drag from the oil