For me, I pulled a 3.0L, and built a 4.3L Vortec to replace it, so no comparison pre Vortec.
I purchased an Edelbrock 1409 to replace the Roc QJet that was on the motor. WIth the adapter plate the Roc wouldn't fit under my doghouse, and the Roc didn't have a choke. When I purchased the 1409 I also purchased the 1485 calibration kit for 4.3L. Total waste of money. That kit must have been made for a pre-Vortec engine, ,it is hugely lean. I ended up taking a WAG, buying a few jet sets and another calibration rod set and springs and worked my way up. Pulled spark plugs a few times after runs at low, middle and high throttle settings. I had no problem with the stock accelerator pump porting, which I believe is set to 5.0L V8 from the factory. IMHO, the stock calibration for a 5.0L is closer to what a Vortec will pull than the recommended kit from Edelbrock.
If you change to Vortec heads you engine will breath well enough that you will have to richen the mid and high range at the least.
Rick